OK. These days, I have realized my functions by reuse the abandoned code. I share it in attachment.

But it's not perfect, because still there are some problems in new code. If it's prossible, please assist me to resolve these.

1. FindDockManager function, how to find the host DockManager in TabGroupPane ?

I cannot find the FindDockManager() in new TabGroupPane class and XamDockManager.GetDockManager(child), so I cannot use the AttachBehaviors to realize view activation in exist tabs. 

protected override void AttachBehaviors(IRegion region, TabGroupPane regionTarget)
{
base.AttachBehaviors(region, regionTarget);

//XamDockManagerActiveAwareBehavior syncBehavior = new XamDockManagerActiveAwareBehavior(regionTarget.FindDockManager(), region);
//syncBehavior.Attach();
}

2. I cannot find Closed event of ContentPane in v12.1, so ...

//When contentPane is closed remove the associated region
//newContentPane.Closed += delegate(object contentPaneSender, PaneClosedEventArgs args)
//{
// OnContentPaneClosed((ContentPane)contentPaneSender, args, region);
//};

But I resolved the first problem by first to active exist pane in view code behind  then if it not exist,  create new region.

• Bootstrapper

public class MainBootstrapper : UnityBootstrapper
{

protected override RegionAdapterMappings ConfigureRegionAdapterMappings()
{
RegionAdapterMappings regionAdapterMappings = base.ConfigureRegionAdapterMappings();
IRegionBehaviorFactory regionBehaviorFactory = Container.TryResolve<IRegionBehaviorFactory>();

if (regionAdapterMappings != null && regionBehaviorFactory != null)
{
regionAdapterMappings.RegisterMapping(typeof(TabGroupPane), new TabGroupPaneRegionAdapter(regionBehaviorFactory));
}

return regionAdapterMappings;
}

}

TabGroupPaneRegionAdapter class in attachment.

• Class MainFrame xaml:

<ig:XamDockManager x:Name="mainDockManager"  >

<ig:XamDockManager.Content>
<ig:DocumentContentHost>

<ig:DocumentContentHost.Panes>

<ig:TabGroupPane Name="mainTabGroup"
prism:RegionManager.RegionName="{Binding TabRegion,Source={StaticResource RegionNames}}"
prism:RegionManager.RegionContext="{Binding CurrentView}"
TabNavigation="Cycle" IsTabStop="True" Location="Right" >
</ig:TabGroupPane>
</ig:DocumentContentHost.Panes>

</ig:DocumentContentHost>
</ig:XamDockManager.Content>
</ig:XamDockManager>

• Class MainFrame code behind

public partial class MainFrame : UserControl
{
TabGroupPane _mainTab;
TabGroupPane MainTab
{
get { return _mainTab ?? (_mainTab = this.mainDockManager.FindName("mainTabGroup") as TabGroupPane); }
}

public MainFrame(MainFrameViewModel viewModel)
{
this.Language = XmlLanguage.GetLanguage(Thread.CurrentThread.CurrentCulture.Name);

InitializeComponent();

DataContext = viewModel;

viewModel.ActivePaneEvent += ViewModelActivePaneEvent;
}

bool ViewModelActivePaneEvent(AzElement data)
{
Debug.Assert(MainTab != null, "MainTab != null");
var cp = MainTab.Panes.FirstOrDefault(p => (p.Content as UIElement).GetContentPaneMetadata().ClassName == data.ClassName);
if (cp != null)
{
return cp.IsActivePane = true;
}

return false;
}
}

• Class MainFrameViewModel:

public sealed class MainFrameViewModel : INotifyPropertyChanged
{

private void SetEntityActiveData(AzElement data)
{
if (ActivePaneEvent != null)
{
if (!this.ActivePaneEvent(data))
{
if (data != null)
{
if (_modulesName.Contains(data.AssemblyName))
{
LoadView();
return;
}

_moduleManager.LoadModuleCompleted += ChildFramePaneLoadModuleCompleted;

_moduleManager.LoadModule(data.AssemblyName);
}
}
}

void LoadView()
{
this._eventAggregator.GetEvent<MenuSelectedEvent>().Publish(new MenuInfo()
{
AssemblyName = CurrentView.AssemblyName,
ClassName = CurrentView.ClassName,
ContentHeader = CurrentView.Name
});

}

}

• In my Unity module:

public class LogMgtModule : IModule
{
private readonly IRegionManager _regionManager;
private readonly SubscriptionToken _subscriptionToken;

public LogMgtModule(IRegionManager regionManager, IEventAggregator eventAggregator)
{
_regionManager = regionManager;

var menuSelectedEvent = eventAggregator.GetEvent<MenuSelectedEvent>();

if (_subscriptionToken != null)
{
menuSelectedEvent.Unsubscribe(_subscriptionToken);
}

_subscriptionToken = menuSelectedEvent.Subscribe(this.MenuSelected, ThreadOption.UIThread, true, menuInfo => menuInfo.AssemblyName == "LogMgtModule");
}

public void Initialize()
{
}

private void MenuSelected(MenuInfo info)
{
var newView = Assembly.GetExecutingAssembly().CreateInstance(info.ClassName) as UserControl;
Debug.Assert(newView != null, "newView != null");

IContentPaneMetadata tabGroupPaneMetadata = new ContentPaneMetadata();
tabGroupPaneMetadata.Header = info.ContentHeader;
tabGroupPaneMetadata.ClassName = info.ClassName;

newView.SetContentPaneMetadata(tabGroupPaneMetadata);

this._regionManager.RegisterViewWithRegion(RegionNames.TabRegion, () => newView);
}
}