Excel 2010 can't open .xlsx files

I’ve upgrade office 2007 to office 2010

After the upgrade i am unable to open any .xlsx files using excel

I have a number of .xlsx files on my desktop and windows doesn’t know which program to use to open them. If i open excel first and go to open and then point to the files, they open fine, just not when i double click on the files directly.

If i create and save a new excel spreadsheet in the default settings as .xlsx it saves it fine but then doesn’t know which program to open it in.

This is only happening in Excel, Word files are fine.

I’m using Windows 7

Thanks

Hello, 

I believe this to be registry related issue.

So, it should be possible to use Registry to fix it.
You could try using regedit.
1.Click on the "Start" button, and then click on "Run." In the dialog box that appears, type "regedit" into the text box, and then click the "OK" button.
2.Navigate to
HKEY_CLASSES_ROOT\Applications\EXCEL.EXE\shell\open\command
3. change to Office14. 

In case the above does not work for you, here are a couple of related resources containing more fix options:
1) http://answers.microsoft.com/en-us/office/forum/office_2010-excel/excel-troubles-xlsx-files-just-wont-open-on-double/2828f328-13ba-48cf-a0b8-fb8a927c 71e5?page=2
2) https://community.spiceworks.com/topic/246692-excel-2010-can-t-open-xlsx-files-only-xls
3) Excel 2013 Pro won't open files when double -clicking the file. 

 Please let me know how these suggestions work for you.

If Excel file can get corrupted due to any internal and external error and can be fixed by only applying any third party Excel File Recovery which can easily fix any kinds of error and corruption use any repair tool to fix your problem instantly. Best utility which can easy resolve all the corruption issues of .XLS/.XLSX files and recover everything like chartsheets, charts, worksheets, cell comments, and other data in MS Excel new black file.

Take a look to the solution:- http://www.recoverydeletedfiles.com/excel-file-recovery-tool.html

It will help you 🙂

You can simply try Kernel for Excel repair software to recover complete data from your corrupt or inaccessible MS Excel file. The software is embedded with two advanced recovery mode i,e. single file and multi file mode. This recovery software supports all MS Excel versions (From 95 to MS Excel 2016). To know more about the software, visit: http://www.xlsx.excelfilerepair.org

First, try Open and Repair tool. This is an inbuilt repair tool that helps me recover my damaged .xls/.xlsx files and open them. As it is an inbuilt tool, so it has some drawback. It might not work in various corruption issues. In that case, we can use a paid software which to repair data from damaged XLSX files.

For more information : http://msofficerecovery.blogspot.com/2014/04/resolving-excel-error-file-error-data-may-have-been-lost.html