Hi Kevin,
1. FindRegionManager modification:
FrameworkElement frameworkElement = dependencyObject as FrameworkElement;
if (frameworkElement != null)
{
  parent = frameworkElement.Parent;
}
if (parent == null)
{
  parent = System.Windows.Media.VisualTreeHelper.GetParent(dependencyObject);
}

UtilityBootsraper Run method changes:
DependencyObject shell = this.CreateShell();
_shell = shell as FrameworkElement;
_shell.LayoutUpdated += Shell_LayoutUpdated;
return;
// move this code to the Shell_LayoutUpdated
//if (shell != null)
//{
//RegionManager.SetRegionManager(shell, this.Container.Resolve<IRegionManager>());
...

FrameworkElement _shell = null;
void Shell_LayoutUpdated(object sender, EventArgs e)
{
  if (_shell != null)
  {
    DependencyObject shell = _shell; // sender as DependencyObject;
    if (shell != null)
    {
      RegionManager.SetRegionManager(shell, this.Container.Resolve<IRegionManager>());
      RegionManager.UpdateRegions();
    }
    ILoggerFacade logger = this.LoggerFacade;
    logger.Log("Initializing modules", Category.Debug, Priority.Low);
    this.InitializeModules();
    logger.Log("Bootstrapper sequence completed", Category.Debug, Priority.Low);
    _shell.LayoutUpdated -= Shell_LayoutUpdated;
    _shell = null;
  }
}

2.  My code is:
private void TilePane_Loaded(object sender, RoutedEventArgs e)
{
  TilePane tile = sender as TilePane;
  Grid parent = tile.Parent as Grid;
  if (parent != null)
  {
    parent.Children.Remove(tile);
    tileView1.Items.Add(tile);
  }
  tile.Loaded -= TilePane_Loaded;
}

Marin

Thanks for your reply Marinii,

I can see where your coming from with both options however I'm struggling to get either to work.

1. In the FindRegionManager method I'm trying to get the parent of the Tilepane and it is always null regardless of wether i do this:

            FrameworkElement frameworkElement = dependencyObject as FrameworkElement;

            if (frameworkElement != null)

            {

                parent = frameworkElement.Parent;

            }

or this:

parent = System.Windows.Media.VisualTreeHelper.GetParent(dependencyObject);

Is this the correct way to use the VisualTree?

2. If I move the Tilepane to the root then yes they are in the RegionManger as their parent is now the Layoutroot grid.  But when I try  and move them to the Tileview in the shell loaded event  like this:

                    this.LayoutRoot.Children.Remove(this.DonutTile);

                    this.ChartTileView.Items.Add(this.DonutTile);

The regions are no longer in the RegionManager when the module initializes.

Is this the best way to move the Tilepanes?

Thanks again

Kevin