Hello,

The UltraListView does have the ability to disable individual checkboxes. You will be able to perform this action by handling the ItemCheckStateChanging event and cancelling this for the items you wish to disable the checkbox on. Please look at the following code to help you perform this action.

private void ultraListView_ItemCheckStateChanging(object sender, Infragistics.Win.UltraWinListView.ItemCheckStateChangingEventArgs e)
        {
            if (e.Item.Index > 0)
                e.Cancel = true;
        }

This code will allow you to check the first checkbox in your list and disable to rest. You can alter this to your preference. 

Please let me know if you need further assistance with this.