Hello haraman21,

You could use the following code sample in order to achieve this:

        private void ultraGrid1_InitializeLayout(object sender, Infragistics.Win.UltraWinGrid.InitializeLayoutEventArgs e)
        {
            e.Layout.Bands[0].Columns["Dosage"].MaskInput = "+nnn";
        }

This way you should have '-' or '+' sign depending on what is the integer(negative or positive respectively).